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Resampling the bioconcentration factors data from Japan's chemical substances control law database to simulate and evaluate the bioconcentration factors derived from minimized aqueous exposure tests
Author(s) -
Hashizume Naoki,
Inoue Yoshiyuki,
Murakami Hidekazu,
Ozaki Hiromichi,
Tanabe Aiko,
Suzuki Yasuyuki,
Yoshida Tomohiko,
Kikushima Erina,
Tsuji Toshiaki
Publication year - 2013
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.2069
Subject(s) - bioconcentration , environmental chemistry , chemistry , percentile , toxicology , bioaccumulation , biology , mathematics , statistics
Abstract Existing standard bioconcentration tests (e.g., the Organization for Economic Cooperation and Development [OECD] test guideline 305) require large numbers of test animals and resources. The minimized aqueous exposure test is a new approach based on the standard bioconcentration test but allows estimation of bioconcentration factor (BCF) by minimized sampling of the test fish. The authors collected BCF data (298 curves from 155 chemicals, using common carp as test species) from Japan's Chemical Substances Control Law database and resampled the data to simulate the calculation of BCF that would be obtained if studies had been designed to obtain kinetic BCF derived from minimized aqueous exposure tests (BCF km ). The correlation was high ( r 2 = 0.967) between BCF derived from standard bioconcentration tests (BCF full ) and BCF km . The average value of the BCF full to BCF km ratio (BCF full :BCF km ) was 1.04 and ranged from 0.54 to 1.93, the 5th and 95th percentiles being 0.74 and 1.45, respectively. The results based on the 5th and 95th percentiles of the BCF full :BCF km ratio suggest that BCF full 2,000 corresponds to BCF km 1,400 to 2,700, whereas BCF full 5,000 corresponds to BCF km 3,400 to 6,800. The authors also emphasize that the standard bioconcentration test should be performed when the resulting BCF km is in the region of regulatory concern. Environ. Toxicol. Chem. 2013;32:406–409. © 2012 SETAC