Premium
Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout
Author(s) -
Burki Richard,
Krasnov Aleksei,
Bettge Kathrin,
Rexroad Caird E.,
Afanasyev Sergej,
Antikainen Mia,
BurkhardtHolm Patricia,
Wahli Thomas,
Segner Helmut
Publication year - 2012
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.1966
Subject(s) - vitellogenin , rainbow trout , biomarker , biology , fish <actinopterygii> , parasite hosting , transcriptome , zoology , physiology , fishery , gene expression , gene , biochemistry , world wide web , computer science
To examine the behavior of the estrogenic biomarker vitellogenin (VTG) under the combined impact of estrogens and pathogens, parasite‐infected or noninfected rainbow trout were exposed to two doses of 17β‐estradiol (E2). Infected and E2‐exposed fish showed significantly lower hepatic VTG mRNA levels than healthy fish. Transcriptome data suggest that this was due to energetic constraints. Reduced responsiveness of the VTG biomarker in parasitized fish might obscure detection of low‐level field exposure. Environ. Toxicol. Chem. 2012; 31: 2318–2323. © 2012 SETAC