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Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka ( Oryzias latipes )
Author(s) -
Grillitsch Britta,
Altmann Dominik,
Schabuss Michael,
Zornig Horst,
SommerfeldStur Irene,
Möstl Erich
Publication year - 2010
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1002/etc.176
Subject(s) - oryzias , metabolite , endocrine system , endocrine disruptor , glucocorticoid , androgen , endocrinology , medicine , biology , fish <actinopterygii> , hormone , chemistry , fishery
Abstract Glucocorticoid metabolites enter the aquatic environment via mammalian excrements. Molecular structures of their C 19 O 3 metabolites strongly resemble the major fish androgen 11‐ketotestosterone. Therefore, we tested the hypothesis that the cortisol metabolite 5α‐androstan‐3,11,17‐trione acts similarly to 11‐ketotestosterone by employing a fish screening assay for endocrine‐active substances. After 21 d, both 11‐oxygenated compounds had masculinized sex characteristics of the anal fin in female medaka in a dose‐dependent manner. Environ. Toxicol. Chem. 2010;29:1613–1620. © 2010 SETAC