Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka ( Oryzias latipes ) | Zendy

Grillitsch Britta | Zendy; Altmann Dominik | Zendy; Schabuss Michael | Zendy; Zornig Horst | Zendy; SommerfeldStur Irene | Zendy; Möstl Erich | Zendy

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Mammalian glucocorticoid metabolites act as androgenic endocrine disruptors in the medaka ( Oryzias latipes )

Author(s) -

Grillitsch Britta,

Altmann Dominik,

Schabuss Michael,

Zornig Horst,

SommerfeldStur Irene,

Möstl Erich

Publication year - 2010

Publication title -

environmental toxicology and chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 171

eISSN - 1552-8618

pISSN - 0730-7268

DOI - 10.1002/etc.176

Subject(s) - oryzias , metabolite , endocrine system , endocrine disruptor , glucocorticoid , androgen , endocrinology , medicine , biology , fish <actinopterygii> , hormone , chemistry , fishery

Glucocorticoid metabolites enter the aquatic environment via mammalian excrements. Molecular structures of their C 19 O 3 metabolites strongly resemble the major fish androgen 11‐ketotestosterone. Therefore, we tested the hypothesis that the cortisol metabolite 5α‐androstan‐3,11,17‐trione acts similarly to 11‐ketotestosterone by employing a fish screening assay for endocrine‐active substances. After 21 d, both 11‐oxygenated compounds had masculinized sex characteristics of the anal fin in female medaka in a dose‐dependent manner. Environ. Toxicol. Chem. 2010;29:1613–1620. © 2010 SETAC

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