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Lower leptin level at discharge in acute anorexia nervosa is associated with early weight‐loss
Author(s) -
Dardennes Roland,
Tolle Virginie,
Lavoisy Guillaume,
Grouselle Dominique,
Alanbar Nebal,
Duriez Philibert,
Gorwood Philip,
Ramoz Nicolas,
Epelbaum Jacques
Publication year - 2021
Publication title -
european eating disorders review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.511
H-Index - 67
eISSN - 1099-0968
pISSN - 1072-4133
DOI - 10.1002/erv.2830
Subject(s) - leptin , weight loss , medicine , ghrelin , endocrinology , body mass index , biomarker , obestatin , logistic regression , anorexia nervosa , gastroenterology , obesity , hormone , eating disorders , chemistry , psychiatry , biochemistry
Objective Predictive values of acute phase metabolic abnormalities of anorexia nervosa (AN) have seldom been studied. As early postrestoration weight loss is associated with poor outcome, discharge biologic parameters were assessed to detect an association with 2‐month follow‐up weight loss as a proxy to poor outcome. Method Fasting plasma levels of leptin, acyl‐ghrelin, obestatin, PYY, oxytocin and BDNF were measured in 26 inpatients, at inclusion, at discharge and 2 months later. A body mass index less than 18 2‐month postdischarge was considered a poor outcome. Results Nineteen patients (73%) had a fair outcome and seven (27%) had a poor one with a mean loss of 0.69 versus 4.54 kg, respectively. Only discharge leptin levels were significantly higher in fair versus poor outcome patients (14.1 vs. 7.0 ng/ml, p = 0.006). The logistic regression model using discharge leptin, acyl‐ghrelin, obestatin, oxytocin, PYY and BDNF levels as predictors of outcome disclosed a nearly significant effect of leptin ( p < 0.10). Receiver operating characteristic analysis showed 11.9 ng/ml was the best value of threshold. Neither clinical variables differed according to outcome. Conclusion Leptin level may be a biomarker of early weight relapse after acute inpatient treatment of AN. Its clinical usefulness in monitoring care in AN should further be determined.