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The Intestinal Microbiome in Bariatric Surgery Patients
Author(s) -
Peat Christine M.,
Kleiman Susan C.,
Bulik Cynthia M.,
Carroll Ian M.
Publication year - 2015
Publication title -
european eating disorders review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.511
H-Index - 67
eISSN - 1099-0968
pISSN - 1072-4133
DOI - 10.1002/erv.2400
Subject(s) - weight loss , obesity , malabsorption , medicine , microbiome , gut flora , population , psychological intervention , weight loss surgery , small intestinal bacterial overgrowth , eating disorders , surgery , physiology , intensive care medicine , environmental health , bioinformatics , biology , immunology , psychiatry , irritable bowel syndrome , gastric bypass
With nearly 39% of the worldwide adult population classified as obese, much of the globe is facing a serious public health challenge. Increasing rates of obesity, coupled with the failure of many behavioural and pharmacological interventions, have contributed to a rise in popularity of bariatric surgery as a treatment for obesity. Surgery‐mediated weight loss was initially thought to be a direct result of mechanical alterations causing restriction and calorie malabsorption. However, the mounting evidence suggests that indirect factors influence the accumulation and storage of fat in patients that have undergone this procedure. Given the established impact the intestinal microbiota has on adiposity, it is likely that this complex enteric microbial community contributes to surgery‐mediated weight loss and maintenance of weight loss postsurgery. In this review, we discuss the physiological and psychological traits exhibited by bariatric surgery candidates that can be influenced by the intestinal microbiota. Additionally, we detail the studies that investigated the impact of bariatric surgery on the intestinal microbiota in humans and mouse models of this procedure. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.