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Placebo Cessation in Binge Eating Disorder: Effect on Anthropometric, Cardiovascular, and Metabolic Variables
Author(s) -
Blom Thomas J.,
Guerdjikova Anna I.,
Mori Nicole,
Casuto Leah S.,
McElroy Susan L.
Publication year - 2015
Publication title -
european eating disorders review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.511
H-Index - 67
eISSN - 1099-0968
pISSN - 1072-4133
DOI - 10.1002/erv.2333
Subject(s) - binge eating , placebo , blood pressure , body mass index , anthropometry , medicine , binge eating disorder , diastole , eating disorders , physical therapy , cardiology , psychiatry , obesity , bulimia nervosa , pathology , alternative medicine
Objective The aim of this study was to evaluate the effects of cessation of binge eating in response to placebo treatment in binge eating disorder (BED) on anthropometric, cardiovascular, and metabolic variables. Method We pooled participant‐level data from 10 randomized, double‐blind, placebo‐controlled trials of medication for BED. We then compared patients who stopped binge eating with those who did not on changes in weight, body mass index (BMI), systolic and diastolic blood pressure, pulse, and fasting lipids and glucose. Result Of 234 participants receiving placebo, 60 (26%) attained cessation from binge eating. Patients attaining cessation showed modestly decreased diastolic blood pressure compared with patients who continued to binge eat. Weight and BMI remained stable in patients who stopped binge eating, but increased somewhat in those who continued to binge eat. Discussion Patients who stopped binge eating with placebo had greater reductions in diastolic blood pressure and gained less weight than patients who continued to binge eat. Self‐report of eating pathology in BED may predict physiologic variables. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.