Premium
Green and fast procedure to obtain N ‐alkylbenzimidazole derivatives under microwave activation
Author(s) -
CalvinoCasilda V.,
MartínAranda R.M.,
LópezPeinado A.J.
Publication year - 2011
Publication title -
environmental progress and sustainable energy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.495
H-Index - 66
eISSN - 1944-7450
pISSN - 1944-7442
DOI - 10.1002/ep.10491
Subject(s) - benzimidazole , alkylation , catalysis , selectivity , microwave , solvent , chemistry , alkali metal , combinatorial chemistry , green chemistry , dry media reaction , organic chemistry , doping , chemical engineering , materials science , reaction mechanism , computer science , engineering , telecommunications , physics , quantum mechanics , reaction rate constant , kinetics , order of reaction , optoelectronics
In this research, we report for the first time the one‐pot microwave‐assisted synthesis of N‐butylbenzimidazole derivatives via alkylation of benzimidazole with 1‐bromobutane over alkali‐metal doped carbons in absence of any solvent. N‐alkylbenzimidazole derivatives are produced in high yields and in very short reaction times when NaCs‐Norit is used as catalyst (ca. 75% in 5 min). Thus the combination of microwaves and basic carbons in dry media leads to the simplest, most eco‐efficient and fastest procedure reported so far for the preparation of benzimidazole derivatives with pharmacological properties. Under these mild reaction conditions, N‐butylbenzimidazoles are obtained with total selectivity to be used in many important industrial applications. © 2010 American Institute of Chemical Engineers Environ Prog, 2011