Premium
Potency measures for developmental toxicity
Author(s) -
Ryan Louise
Publication year - 1993
Publication title -
environmetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 58
eISSN - 1099-095X
pISSN - 1180-4009
DOI - 10.1002/env.3170040409
Subject(s) - potency , ranking (information retrieval) , estimator , toxicology , statistics , econometrics , biology , pharmacology , computer science , mathematics , machine learning , genetics , in vitro
Potency measures provide a useful means of ranking chemicals, drugs and other substances with respect to the danger they pose to humans. While several authors have proposed estimators of carcinogenic potency, the task of ranking developmental toxicants has received little attention. The purpose of this paper is to develop a quantitative measure of developmental potency, based on a correlated multinominal model that allows for dose effects on foetal death, variation and malformation rates. The proposed estimator is illustrated with data from several studies conducted through the National Toxicology Program.