Open AccessVEGF sticky‐trap: the first report of a non‐systemically acting angiogenesis inhibitor
Author(s) -
Favara David M,
Harris Adrian L
Publication year - 2014
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201404026
Subject(s) - angiogenesis , macular degeneration , medicine , neovascularization , diabetic retinopathy , angiogenesis inhibitor , cancer research , blood vessel , side effect (computer science) , pharmacology , diabetes mellitus , endocrinology , ophthalmology , computer science , programming language
Current therapeutic anti‐angiogenic biologics used for the treatment of pathological ocular angiogenesis such as in diabetic retinopathy and wet macular degeneration often lead to detrimental side effects due to their interference with normal blood vessel physiology. In this issue of EMBO Molecular Medicine , Michael et al report on a novel angiogenesis inhibitor with unique properties that allow for local inhibition of angiogenesis without detectable systemic side effects.