Open AccessProstaglandin E 2 promotes post‐infarction cardiomyocyte replenishment by endogenous stem cells
Author(s) -
Hsueh YingChang,
Wu Jasmine M F,
Yu ChunKeung,
Wu Kenneth K,
Hsieh Patrick C H
Publication year - 2014
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201303687
Subject(s) - stem cell , progenitor cell , microbiology and biotechnology , endogeny , regeneration (biology) , prostaglandin e2 , biology , prostaglandin , endocrinology
Although self‐renewal ability of adult mammalian heart has been reported, few pharmacological treatments are known to promote cardiomyocyte regeneration after injury. In this study, we demonstrate that the critical period of stem/progenitor cell‐mediated cardiomyocyte replenishment is initiated within 7 days and saturates on day 10 post‐infarction. Moreover, blocking the inflammatory reaction with COX ‐2 inhibitors may also reduce the capability of endogenous stem/progenitor cells to repopulate lost cells. Injection of the COX ‐2 product PGE 2 enhances cardiomyocyte replenishment in young mice and recovers cell renewal through attenuating TGF ‐β1 signaling in aged mice. Further analyses suggest that cardiac stem cells are PGE 2 ‐responsive and that PGE 2 may regulate stem cell activity directly through the EP 2 receptor or indirectly by modulating its micro‐environment in vivo . Our findings provide evidence that PGE 2 holds great potential for cardiac regeneration.