Open AccessmRNA 3′end processing: A tale of the tail reaches the clinic
Author(s) -
Hollerer Ina,
Grund Kerstin,
Hentze Matthias W.,
Kulozik Andreas E
Publication year - 2014
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201303300
Subject(s) - messenger rna , gene expression , biology , innate immune system , rna processing , microbiology and biotechnology , gene , computational biology , genetics , immune system
Recent advances reveal mRNA 3′end processing as a highly regulated process that fine‐tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3′end processing, controlling the quality and the quantity of substrate mRNA s. The regulation of 3′end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3′end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3′end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine.