Open AccessInitial HIV mucosal infection and dendritic cells
Author(s) -
Cunningham Anthony L,
Harman Andrew,
Nasr Najla
Publication year - 2013
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201202763
Subject(s) - human immunodeficiency virus (hiv) , dendritic cell , immunology , virology , medicine , biology , immune system
from bone marrow and divided into two major types: the myeloid and plasmacytoid DCs (which are major producers of type I interferons). Myeloid DCs consist of sub-populations found in diverse anatomical locations throughout the body, and especially in tissues in contact with the external environment. These include the blood, secondary lymphoid tissue and especially the anogenital and intestinal epithelium. DC sub-populations have been best defined in mice, but the human homologues are now being described (Ziegler-Heitbrock et al, 2010).