Open AccessResolution of inflammation: an integrated view
Author(s) -
OrtegaGómez Almudena,
Perretti Mauro,
Soehnlein Oliver
Publication year - 2013
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201202382
Subject(s) - inflammation , microbiology and biotechnology , chemokine , infiltration (hvac) , chemotaxis , function (biology) , apoptosis , biology , phenotype , immunology , receptor , genetics , physics , gene , thermodynamics
Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution. We describe how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance. Uptake of apoptotic neutrophils by macrophages reprograms macrophages towards a resolving phenotype, a key event to restore tissue homeostasis. Finally, we highlight the therapeutic potential that derives from understanding the mechanisms of resolution.