Open AccessA novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL‐10 dependent derivatives of inflammatory monocytes
Author(s) -
Fevre Cindy,
Almeida Ana S.,
Taront Solenne,
Pedron Thierry,
Huerre Michel,
Prevost MarieChristine,
Kieusseian Aurélie,
Cumano Ana,
Brisse Sylvain,
Sansonetti Philippe J.,
Tournebize Régis
Publication year - 2013
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201202023
Subject(s) - rhinoscleroma , klebsiella pneumoniae , immunology , biology , bone marrow , medicine , gene , biochemistry , escherichia coli
Rhinoscleroma is a human specific chronic disease characterized by the formation of granuloma in the airways, caused by the bacterium Klebsiella pneumoniae subspecies rhinoscleromatis , a species very closely related to K. pneumoniae subspecies pneumoniae . It is characterized by the appearance of specific foamy macrophages called Mikulicz cells. However, very little is known about the pathophysiological processes underlying rhinoscleroma. Herein, we characterized a murine model recapitulating the formation of Mikulicz cells in lungs and identified them as atypical inflammatory monocytes specifically recruited from the bone marrow upon K. rhinoscleromatis infection in a CCR2‐independent manner. While K. pneumoniae and K. rhinoscleromatis infections induced a classical inflammatory reaction, K. rhinoscleromatis infection was characterized by a strong production of IL‐10 concomitant to the appearance of Mikulicz cells. Strikingly, in the absence of IL‐10, very few Mikulicz cells were observed, confirming a crucial role of IL‐10 in the establishment of a proper environment leading to the maturation of these atypical monocytes. This is the first characterization of the environment leading to Mikulicz cells maturation and their identification as inflammatory monocytes.