Open AccessBalancing the fat: lipid droplets and human disease
Author(s) -
Krahmer Natalie,
Farese Robert V.,
Walther Tobias C.
Publication year - 2013
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201100671
Subject(s) - lipid droplet , organelle , lipid metabolism , lipid accumulation , cytosol , chemistry , microbiology and biotechnology , biology , biochemistry , enzyme
Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.