Open AccessRegulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins
Author(s) -
Kawai Taro,
Akira Shizuo
Publication year - 2011
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201100160
Subject(s) - innate immune system , pattern recognition receptor , signal transduction , microbiology and biotechnology , biology , receptor , immune receptor , immune system , signal transducing adaptor protein , immunology , genetics
The innate immune system recognizes microbial components through pattern‐recognition receptors (PRRs), including membrane‐bound Toll‐like receptors and cytosolic receptors such as RIG‐I‐like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense. The tripartite motif (TRIM) family is a diverse family of RING finger domain‐containing proteins, which are involved in a variety of cellular functions. Importantly, recent studies have shown that they are also involved in the regulation of innate immune responses through the modulation of PRR signalling pathways.