Open AccessDivide and conquer: the genetic basis of molecular subclassification of breast cancer
Author(s) -
Kristensen Vessela N.
Publication year - 2011
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201100128
Subject(s) - biology , breast cancer , gene , cancer research , cancer , disease , adjuvant , computational biology , bioinformatics , medicine , genetics , immunology
Since the luminal B tumours are associated with poor recurrence‐free and disease‐specific survivals in all adjuvant systemic treatment categories including hormone therapy, the identification of specific signalling pathways driving luminal B biology is paramount to improve treatment. Sircoulomb et al. and Holland et al. have independently identified the ZNF703 gene, located in chromosomal region 8p12, as preferentially amplified in luminal B tumours. See related articles in EMBO Mol Med (Holland et al. (2011) EMBO Mol Med 3: 167‐180 and Sircoulomb et al. (2011) EMBO Mol Med 3: 153‐166 )