Divide and conquer: the genetic basis of molecular subclassification of breast cancer

Since the luminal B tumours are associated with poor recurrence‐free and disease‐specific survivals in all adjuvant systemic treatment categories including hormone therapy, the identification of specific signalling pathways driving luminal B biology is paramount to improve treatment. Sircoulomb et al. and Holland et al. have independently identified the ZNF703 gene, located in chromosomal region 8p12, as preferentially amplified in luminal B tumours. See related articles in EMBO Mol Med (Holland et al. (2011) EMBO Mol Med 3: 167‐180 and Sircoulomb et al. (2011) EMBO Mol Med 3: 153‐166 )