Open AccessPrion protein in Alzheimer's pathogenesis: a hot and controversial issue
Author(s) -
Benilova Iryna,
De Strooper Bart
Publication year - 2010
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201000088
Subject(s) - pathogenesis , prion protein , alzheimer's disease , neuroscience , medicine , biology , disease , immunology , pathology
The role for cellular prion protein PrP c in β‐amyloid (Aβ) oligomer‐induced synaptic impairment is a topic of great interest and some controversy. In this issue of EMBO Molecular Medicine Aguzzi and co‐workers explore the contribution of PrP c to deficient long term potentiation (LTP) and soluble Aβ levels in an Alzheimer's disease mouse model and show that the role of prions in Aβ related toxicity is far from ‘black and white’ suggesting complex interpretations of the data available thus far. See related article in EMBO Mol Med (Calella AM et al (2010) EMBO Mol Med 2: 306–314 )