Open AccessImaging metabolic syndrome
Author(s) -
Han Weiping,
Chuang KaiHsiang,
Chang YoungTae,
Olivo Malini,
Velan S. Sendhil,
Bhakoo Kishore,
Townsend David,
Radda George K.
Publication year - 2010
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.201000074
Subject(s) - adipose tissue , metabolic syndrome , diabetes mellitus , bioinformatics , medicine , pathological , obesity , intensive care medicine , pathology , biology , endocrinology
Metabolic syndrome is a fast growing public health burden for almost all the developed countries and many developing nations. Despite intense efforts from both biomedical and clinical scientists, many fundamental questions regarding its aetiology and development remain unclear, partly due to the lack of suitable imaging technologies to visualize lipid composition and distribution, insulin secretion, β‐cell mass and functions in vivo . Such technologies would not only impact on our understanding of the complexity of metabolic disorders such as obesity and diabetes, but also aid in their diagnosis, drug development and assessment of treatment efficacy. In this article we discuss and propose several strategies for visualization of physiological and pathological changes that affect pancreas and adipose tissue as a result of the development of metabolic diseases.