Open AccessMaking the most of what you've got: Optimizing residual OXPHOS function in mitochondrial diseases
Author(s) -
Moraes Carlos T.
Publication year - 2009
Publication title -
embo molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.923
H-Index - 107
eISSN - 1757-4684
pISSN - 1757-4676
DOI - 10.1002/emmm.200900049
Subject(s) - miami , miller , library science , oxidative phosphorylation , gerontology , medicine , biology , humanities , philosophy , biochemistry , computer science , ecology , environmental science , soil science
Abstract Patients affected by mitochondrial OXPHOS disorders are still faced with a grim lack of therapeutic options. In this Closeup, Carlos Moraes revisits the recent data by Giovanni Manfredi on PKA's functions in the mitochondria and now its modulation can improve respiration and ATP production in COX‐defective cells.