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The gatekeepers of mitochondrial calcium influx: MICU 1 and MICU 2
Author(s) -
Ahuja Malini,
Muallem Shmuel
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1002/embr.201438446
Subject(s) - calcium , chemistry , organic chemistry
The receptor‐evoked C a 2+ signal is sensed and translated by mitochondria. Physiological cytoplasmic C a 2+ ([ C a 2+ ] c ) oscillations result in mitochondrial C a 2+ ([ C a 2+ ] m ) oscillations, while large and sustained [ C a 2+ ] c increase results in a pathologic increase in basal [ C a 2+ ] m and in C a 2+ accumulation. The physiological [ C a 2+ ] m signal regulates [ C a 2+ ] c and stimulates oxidative metabolism, while excess C a 2+ accumulation causes cell stress leading to cell death. [Ca 2+ ] m is determined by Ca 2+ uptake mediated by the mitochondria C a 2+ uniporter ( MCU ) channel and by Na + ‐ and H + ‐coupled C a 2+ extrusion [1][Drago I, 2011].