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PICK 1 links Argonaute 2 to endosomes in neuronal dendrites and regulates mi RNA activity
Author(s) -
Antoniou Anna,
Baptista Marcio,
Carney Nicholas,
Hanley Jonathan G
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1002/embr.201337631
Subject(s) - sociology , library science , computer science
MicroRNAs fine‐tune gene expression by inhibiting the translation of mRNA targets. Argonaute (Ago) proteins are critical mediators of microRNA‐induced post‐transcriptional silencing and have been shown to associate with endosomal compartments, but the molecular mechanisms that underlie this process are unclear, especially in neurons. Here, we report a novel interaction between Ago2 and the BAR‐domain protein, PICK1. We show that PICK1 promotes Ago2 localization at endosomal compartments in neuronal dendrites and inhibits Ago2 function in translational repression following neuronal stimulation. We propose that PICK1 provides a link between activity‐dependent endosomal trafficking and local regulation of translation in neurons.