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Type 1 metabotropic glutamate receptors (m G lu1) trigger the gating of G lu D 2 delta glutamate receptors
Author(s) -
Ady Visou,
Perroy Julie,
Tricoire Ludovic,
Piochon Claire,
Dadak Selma,
Chen Xiaoru,
Dusart Isabelle,
Fagni Laurent,
Lambolez Bertrand,
Levenes Carole
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1002/embr.201337371
Subject(s) - metabotropic glutamate receptor , metabotropic glutamate receptor 6 , metabotropic glutamate receptor 1 , metabotropic glutamate receptor 2 , metabotropic receptor , glutamate receptor , ionotropic effect , gating , metabotropic glutamate receptor 7 , metabotropic glutamate receptor 3 , microbiology and biotechnology , metabotropic glutamate receptor 5 , class c gpcr , metabotropic glutamate receptor 4 , receptor , biology , chemistry , biochemistry , biophysics
The orphan G lu D 2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand‐gated G lu D 2 currents have never been evidenced, and whether G lu D 2 operates as an ion channel has been a long‐standing question. Here, we show that G lu D 2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, G lu D 2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.