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Precision attack on calcineurin in macrophages: a new anti‐inflammatory weapon
Author(s) -
Schultze Joachim L
Publication year - 2014
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/embj.201488178
Subject(s) - biology , calcineurin , virology , immunology , medicine , transplantation , surgery
Inflammation is a hallmark of many common diseases ranging from arthritis, atherosclerosis, or obesity to Alzheimer's disease and cancer. Identifying anti‐inflammatory mechanisms is therefore an important and timely task of modern biomedicine. In this issue of The EMBO Journal , a study conducted by Escolano and colleagues target a particular interaction site of calcineurin with NFAT in macrophages to elicit profound anti‐inflammatory effects (Escolano et al , 2014).