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The Arabidopsis PEPR pathway couples local and systemic plant immunity
Author(s) -
Ross Annegret,
Yamada Kohji,
Hiruma Kei,
YamashitaYamada Misuzu,
Lu Xunli,
Takano Yoshitaka,
Tsuda Kenichi,
Saijo Yusuke
Publication year - 2013
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/embj.201284303
Subject(s) - biology , arabidopsis , plant immunity , immunity , genetics , immune system , gene , mutant
Recognition of microbial challenges leads to enhanced immunity at both the local and systemic levels. In Arabidopsis, EFR and PEPR 1/ PEPR 2 act as the receptor for the bacterial elongation factor EF ‐Tu (elf18 epitope) and for the endogenous PROPEP ‐derived Pep epitopes, respectively. The PEPR pathway has been described to mediate defence signalling following microbial recognition. Here we show that PROPEP 2/ PROPEP 3 induction upon pathogen challenges is robust against jasmonate, salicylate, or ethylene dysfunction. Comparative transcriptome profiling between Pep2‐ and elf18‐treated plants points to co‐activation of otherwise antagonistic jasmonate‐ and salicylate‐mediated immune branches as a key output of PEPR signalling. Accordingly, as well as basal defences against hemibiotrophic pathogens, systemic immunity is reduced in pepr1 pepr2 plants. Remarkably, PROPEP 2/ PROPEP 3 induction is essentially restricted to the pathogen challenge sites during pathogen‐induced systemic immunity. Localized Pep application activates genetically separable jasmonate and salicylate branches in systemic leaves without significant PROPEP 2/ PROPEP 3 induction. Our results suggest that local PEPR activation provides a critical step in connecting local to systemic immunity by reinforcing separate defence signalling pathways.