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An examination of the potential “genotoxic” carcinogenicity of a biopesticide derived from the neem tree
Author(s) -
Rosenkranz Herbert S.,
Klopman Gilles
Publication year - 1995
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850260311
Subject(s) - biopesticide , toxicology , mutagen , carcinogen , biology , pesticide , genetics , agronomy
Structural analyses of azadirachtin, a promising biopesticide recently introduced into the United States, indicates that this natural product has the potential for acting as a “genotoxic” carcinogen. In view of the fact that genotoxic carcinogens are regarded as presenting a potential carcinogenic risk to humans, the present finding suggests that the possible metabolism of azadirachtin to DNA‐reactive products be evaluated experimentally. © 1995 Wiley‐Liss, Inc.