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Relationships among in vitro mutagenicity assays: Quantitative vs. qualitative test results
Author(s) -
Benigni Romualdo,
Andreoli Cristina,
Giuliani Alessandro
Publication year - 1995
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850260209
Subject(s) - sister chromatid exchange , salmonella , biology , in vitro , genetics , point mutation , sister chromatids , mutation , chinese hamster ovary cell , microbiology and biotechnology , mutagenesis , cell culture , chromosome , gene , bacteria
In previous investigations, we studied the relationships between the profiles of the qualitative responses of in vitro short‐term tests (mutation in Salmonella typhimurium , chromosomal aberrations in CHO cells, sister chromatid exchanges in CHO cells, and mutation in mouse lymphoma cells) and common sets of chemicals. In this paper, we address the study of the quantitative responses (potency). We show that two analyses point to similar patterns of relationships: the mutation in mouse lymphoma cells assay is most similar to the CHO sister chromatid exchange assay, and the Salmonella assay is most similar to the CHO chromosomal aberrations assay. © 1995 Wiley‐Liss, Inc.