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Enhancement of the mutagenicity of amino acid pyrolysates by phthalate esters
Author(s) -
Sato Takahiko,
Nagase Hisamitsu,
Sato Kayoko,
Niikawa Miki,
Kito Hideaki
Publication year - 1994
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850240410
Subject(s) - phthalic acid , chemistry , dimethyl phthalate , ames test , phthalate , pyrene , mutagen , organic chemistry , carcinogen , amino acid , phthalic anhydride , salmonella , biochemistry , chromatography , bacteria , biology , genetics , catalysis
The ability of phthalic acid, phthalic acid anhydride, and various phthalate esters to enhance the mutagenicity of many amino acid pyrolysates was observed with the Ames test ( Salmonella typhimurium TA98), but not the SOS Chromotest. Phthalate enhancement of the mutagenicity of 4‐nitroquinoline‐1‐oxide, 2‐nitrofluorene, and benzo[a]pyrene was not observed with either test. The mutagenicity‐enhancing ability may be related to the induction of enzymes such as P450IIB, that metabolize amino acid pyrolysates. By quantitative structure activity relationship (QSAR) analysis, a good correlation was observed between the mutagenicity‐enhancing activity of phthalates and their octanol‐water partition coefficients. © 1994 Wiley‐Liss, Inc.