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Activity of aromatic amines in the eye: w/w + somatic assay of drosophila melanogaster
Author(s) -
RodriguezArnaiz Rosario,
Aranda Judith Hernández
Publication year - 1994
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850240110
Subject(s) - aromatic amine , chemistry , carcinogen , bicyclic molecule , drosophila melanogaster , amine gas treating , nitro , mutagen , biotransformation , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , enzyme , alkyl , gene
Aromatic amines represent a category of classical environmental hazards which require biotransformation in order to exert their mutagenic and carcinogenic effects. The mutagenic activity of several aromatic amines was tested by means of the w/w + somatic assay of Drosophila melanogaster employing a wild‐type strain Leiden Standard (LS) and an insecticide‐resistant stock Hikone‐R (HK‐R). Four monocyclicortho‐anisidine (O‐AN), ortho‐toluidine (O‐TO), 2, 4‐diaminoanisole (2, 4‐DAA) and 4‐nitro‐o‐phenylenediamine (4‐N‐o‐PDA), and one bicyclic‐ 4, 4′‐oxidianiline (4, 4′‐ODA) aromatic amines were tested by chronic exposure. Two separate experiments were run, and concurrent controls were treated with the solvent mixture. Results show that the ortho‐anilines (O‐AN and O‐TO) were active in the assay, while the diamines containing a methoxy (2, 4‐DAA) or a nitro group (4‐N‐o‐PDA) were inactive. The bicyclic aromatic amine, 4, 4′‐ODA, was the most potent. The genotoxic responsiveness of both strains was very similar. © 1994 Wiley‐Liss, Inc.