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Development and impact of the gene‐tox program, genetic activity profiles, and their computerized data bases
Author(s) -
Waters Michael D.
Publication year - 1994
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850230615
Subject(s) - agency (philosophy) , identification (biology) , international agency , hazard , risk assessment , biology , computational biology , genetics , cancer , computer science , computer security , ecology , philosophy , botany , epistemology
This invited historical review traces the development and impact of two major data bases in the field of genetic toxicology. Discussed from a personal perspective are the Environmental Protection Agency (EPA) Gene‐Tox Program and the EPA/International Agency for Research on Cancer Genetic Activity Profiles (GAPs) and their respective data bases. Whereas Gene‐Tox was focused on the assessment of short‐term tests and their role in predicting carcinogens and mutagens, GAPs and the GAP data base were designed specifically to aid in the evaluation of individual chemicals. Both data bases have been computerized. Gene‐Tox is available on TOXNET and GAP is available in a personal computer format from the author. The Gene‐Tox and GAP data bases appear to have had substantial impact, particularly on hazard identification activities in cancer risk assessment. © 1994 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.