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UV‐responsive element (TGACAACA) from rat fibroblasts to human melanomas
Author(s) -
Ronai Zeev,
Rutberg Susan,
Yang Yang Ming
Publication year - 1994
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850230302
Subject(s) - creb , dna replication , transcription factor , transcription (linguistics) , biology , dna , dna damage , microbiology and biotechnology , dna binding protein , cell cycle , cell , genetics , gene , linguistics , philosophy
When taken together, several lines of evidence suggest that the URE-bound proteins are associated with DNA replication. (1) A trans-acting factor of 60 kDa (which may include the 68-kDa URE-binding proteins) was found to be induced by UV and to mediate polyoma DNA replication; (2) the URE was able to compete for the binding of factors that promote polyoma replication in rodent cells; (3) URE-bound proteins are expressed to a higher extent at the S phase of the cell cycle; and (4) they are induced following treatment with aphidicholin. These observations may suggest that the URE may play a role in growth "release" (as opposed to growth "arrest") which would assist in restoring normal growth following DNA damage. It is clear that URE-bound proteins consist of multiple transcription factors, some of which are well characterized (i.e., jun, CREB, and fos families); however, it is likely that the growth release phenomenon we relate to is also mediated by (1) other members of these transcription factor families which have not been identified as yet and (2) a specific combination of known transcription factors which bind to this response element under certain circumstances. This hypothesis is outlined in the enclosed model (Fig. 3).