Negative dose‐response relationship for radiation‐induced micronuclei in polychromatic erythrocytes of mice | Zendy

McFee A. F. | Zendy; Cook S. B. | Zendy; Abbott M. G. | Zendy

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Negative dose‐response relationship for radiation‐induced micronuclei in polychromatic erythrocytes of mice

Author(s) -

McFee A. F.,

Cook S. B.,

Abbott M. G.

Publication year - 1994

Publication title -

environmental and molecular mutagenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1

H-Index - 87

eISSN - 1098-2280

pISSN - 0893-6692

DOI - 10.1002/em.2850230209

Subject(s) - micronucleus test , micronucleus , radiation exposure , toxicology , bone marrow , andrology , radiation dose , dose–response relationship , biology , toxicity , physiology , immunology , medicine , nuclear medicine , endocrinology

Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X‐rays and at 6‐hr intervals from 12‐60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared much later following 6 Gy than after 2 Gy exposures, implicating cell cycle delay as the cause of the negative dose‐response relationship.

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