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Negative dose‐response relationship for radiation‐induced micronuclei in polychromatic erythrocytes of mice
Author(s) -
McFee A. F.,
Cook S. B.,
Abbott M. G.
Publication year - 1994
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850230209
Subject(s) - micronucleus test , micronucleus , radiation exposure , toxicology , bone marrow , andrology , radiation dose , dose–response relationship , biology , toxicity , physiology , immunology , medicine , nuclear medicine , endocrinology
Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X‐rays and at 6‐hr intervals from 12‐60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared much later following 6 Gy than after 2 Gy exposures, implicating cell cycle delay as the cause of the negative dose‐response relationship.