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In vitro cytotoxic and cell transforming activities exerted by the pesticides cyanazine, dithianon, diflubenzuron, procymidone, and vinclozolin on BALB/c 3T3 cells
Author(s) -
Perocco Paolo,
Colacci Annamaria,
Grilli Sandro
Publication year - 1993
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850210111
Subject(s) - vinclozolin , cytotoxic t cell , procymidone , diflubenzuron , pesticide , chemistry , in vitro , biology , biochemistry , agronomy
Abstract Cytotoxic and cell transforming activities of the pesticides cyanazine, diflubenzuron, dithianon, procymidone, and vinclozolin were investigated in vitro by utilizing the BALB/c 3T3 cell transformation test performed in the presence or in the absence of S‐9 mix as an exogenous bioactivation system for the chemicals. All the assayed pesticides were cytotoxic in the absence of S‐9 mix, whereas only dithianon exerted cytotoxic effects in the presence of metabolic activation. All the chemicals tested did induce BALB/c 3T3 cell transformation, to a various extent, in the absence of S‐9 mix. Cell transforming ability of cyanazine and diflubenzuron was not detectable in the presence of S‐9. © 1993 Wiley‐Liss, Inc.