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Overview: Industrial perspectives on existing in vivo gene mutation assays
Author(s) -
Li A. P.,
Kier Larry D.
Publication year - 1991
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850180415
Subject(s) - in vivo , computational biology , mutation , gene mutation , biology , gene , microbiology and biotechnology , genetics
In vivo gene mutation assays are considered the most definitive for the evaluation of human health risks. Suggestions are provided here for the critical evaluation of the application of established in vivo gene mutation assays and alternative approaches in the evaluation of industrial chemicals. Objective evaluation of the assays and approaches based on sound science and practical issues will allow better application of the existing assays. Such an evaluation may also help illuminate areas of improvement, as well as help guide the development of future assays.