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Lack of genotoxicity of cross‐linked acrylate polymers in four short‐term genotoxicity assays
Author(s) -
Thompson E. D.,
Seymour J. L.,
Aardema M. J.,
Leboeuf R. A.,
Evans B. L. B.,
Cody D. B.,
Littlefield L. G.
Publication year - 1991
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850180306
Subject(s) - genotoxicity , tmpta , chemistry , acrylamide , in vivo , microbiology and biotechnology , ames test , biochemistry , polymer , biology , acrylate , genetics , toxicity , organic chemistry , salmonella , monomer , copolymer , bacteria
Three cross‐linked polyacrylate polymers containing either methylenebis‐acrylamide (MBA), trimethylolpropane triacrylate (TMPTA), or triallylamine (TAA) cross‐linkers were tested for genotoxicity with the Salmonella mammalian microsome assay, the L5178Y mouse lymphoma TK ± assay, the unscheduled DNA synthesis assay in primary cultures of rat hepatocytes, and the in vivo bone marrow cytogenetic assay. The results indicate that none of the three polymers was genotoxic in these assays.