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Inhibitory effect of lichen constituents on mutagenicity induced by heterocyclic amines
Author(s) -
Osawa T.,
Kumon H.,
Reece C. A.,
Shibamoto T.,
Snyder R. D.
Publication year - 1991
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850180107
Subject(s) - chemistry , pyrene , antimutagen , mutagen , ames test , salmonella , biochemistry , carcinogen , amine gas treating , linoleic acid , aromatic amine , microsome , organic chemistry , bacteria , enzyme , biology , fatty acid , genetics
Physodic acid, one of the main constituents of Hypogymnia enteromorpha , inhibited the mutagenicity of indirect mutagens, including benzo[a]pyrene and heterocyclic amines in Salmonella typhimurium TA 98. In contrast, it was not effective against direct mutagens such as 6‐nitropiperonal and adriamycin. Its antimutagenicity was not associated with free‐radical scavenging or antioxidative activities. Physodic acid seemed to inhibit the formation of reactive metabolites, such as N‐hydroxy‐Trp‐P‐2, by blocking the hepatic microsomal oxidation systems. Another component of H. enteromorpha , physodalic acid, also inhibited mutagenicity of a heterocyclic amine, Trp‐P‐2, in S. typhimurium TA 98, even though it was reportedly mutagenic in S. typhimurium TA 100.