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Mutagenicity in salmonella and sister chromatid exchange in mice for 1,4‐, 1,3‐, 2,4‐, and 3,4‐dimethylphenanthrenes
Author(s) -
Sinsheimer J. E.,
Giri A. K.,
Hooberman B. H.,
Jung K.Y.,
Gopalaswamy R.,
Koreeda M.,
Brockman H. E.
Publication year - 1991
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850170205
Subject(s) - phenanthrenes , sister chromatid exchange , genotoxicity , salmonella , mutagenesis , chemistry , ames test , structural isomer , in vivo , carcinogen , stereochemistry , biochemistry , biology , toxicology , genetics , dna , mutation , toxicity , organic chemistry , gene , bacteria , phenanthrene
The mutagenicity in Salmonella and in vivo sister chromatid exchange in the bone‐marrow cells of mice was determined for 1,4‐, 1,3‐, 2,4‐, and 3,4‐dimethylphenanthrene (DMPh) with the objective to study the relative importance of substitution at the 1 and 4 positions of this series of methylated phenanthrenes. For both tests, 1,4‐DMPh was decidedly more genotoxic than the remaining regioisomers. While the well recognized role of steric crowding in the bay region is a factor in this enhanced genotoxicity, equally important is substitution at the 1 position with its potential to inhibit detoxication through 9,10‐diol formation.