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Genotoxicity of the fungicide dichlofluanid in seven assays
Author(s) -
Heil J.,
Reifferscheid G.,
Hellmich D.,
Hergenröder M.,
Zahn R. K.,
Setlow R. B.
Publication year - 1991
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850170104
Subject(s) - genotoxicity , fungicide , carcinogen , chemistry , bioassay , toxicology , biology , chromatography , environmental chemistry , biochemistry , toxicity , botany , genetics , organic chemistry
Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA‐altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline viscosimetry, umu ‐test, alkaline filter elution, FADU‐test, 32 P‐postlabeling, and electron microscopy) shows clear evidence of genotoxicity. These data indicate that application of the fungicide dichlofluanid may be mutagenic and/or carcinogenic for exposed humans.