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In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone
Author(s) -
Bali Deeksha,
Singh Jai Rup,
Singh Harbhajan,
Sandhu Dharambir,
Reidy J. A.
Publication year - 1990
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850160406
Subject(s) - genotoxicity , micronucleus test , sister chromatid exchange , in vivo , clastogen , hydrocortisone , in vitro , pharmacology , ames test , biology , toxicology , genetics , medicine , salmonella , toxicity , biochemistry , bacteria
Genotoxic evaluation of a widely used glucocorticoid, hydrocortisone, was undertaken using a battery of in vitro and in vivo test systems. Human lymphocyte cultures and mouse bone marrow studies (micronuclei and sister chromatid exchange analyses) showed the drug to be very potent clastogen. However, the Ames/ Salmonella assay both with and without S9 did not show an increase in the His + revertants.