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Significant differences in the structural basis of the induction of sister chromatid exchanges and chromosomal aberrations in chinese hamster ovary cells
Author(s) -
Rosenkranz Herbert S.,
Ennever Fanny K.,
Dimayuga Mario,
Klopman Gilles,
Hoiden H. E.
Publication year - 1990
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850160304
Subject(s) - chinese hamster ovary cell , sister chromatids , sister chromatid exchange , genetics , biology , dna , gene , cell culture , chromosome
The structural basis of the induction of sister chromatid exchanges (SCE) and chromosomal aberrations (Cvt) in Chinese hamster ovary cells was investigated by the CASE (Computer Automated Structure Evaluation) method, on artificial‐intelligence‐based system. Using the relevant National Toxicology Program data bases CASE identified a set of structural determinants responsible for the induction of SCE and another one for Cvt. A comparison between the structural determinants associated with SCE and Cvt revealed an overlap of only 22.6%, while the overlap between SCE and the determinants of mufagenicity in Salmonella is 54.5%. This indicates a) that the structural bases of the two phenomena differ and b) that it is likely that SCE, but not Cvt, involves a significant electrophilic/DNA‐damaging component.