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Concentration‐response curves for ethylene‐oxide‐induced heritable translocations and dominant lethal mutations
Author(s) -
Generoso W. M.,
Cain K. T.,
Cornett C. V.,
Cacheiro N. L. A.,
Hughes L. A.,
Albertini R. J.,
Casciano D. A.
Publication year - 1990
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850160209
Subject(s) - clastogen , chromosomal translocation , inhalation , genetics , biology , mutation , ethylene oxide , dominant lethal , toxicology , toxicity , chemistry , medicine , genotoxicity , gene , organic chemistry , anatomy , copolymer , polymer
Abstract Male mice were subjected to repeated inhalation exposures to different concentrations (165, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5‐week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable translocations. The concentration‐response curves for both endpoints are not linear but are markedly concave upward. Significant increases in dominant lethals were detected at all concentrations, except the lowest one. In comparison, the incidences of heritable translocations were significantly increased at all concentrations.