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Quantitative estimation of the genetic risk associated with the induction of heritable translocations at low‐dose exposure: Ethylene oxide as an example
Author(s) -
Rhomberg Lorenz,
Dellarco Vicki L.,
SiegelScott Cheryl,
Dearfield Kerry L.,
JacobsonKram David,
Malling H. V.
Publication year - 1990
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850160208
Subject(s) - risk assessment , biology , toxicology , chromosomal translocation , quantitative trait locus , genetics , computer science , gene , computer security
This paper explores how quantitative risk assessment methods might be extended to analysis of risks to the human germ line. High inhalation exposures to ethylene oxide are reported to cause heritable translocations in male mice with a steep and nonlinear dose‐response curve. We explore quantitative estimation of risk to humans from low exposures based on these animal data, addressing questions of tissue dosimetry for this alkylating agent, expected equivalency of doses across species, germ‐cell sensitivity, and extrapolation of dose‐response relationship to low exposure levels. Various dose‐response models are discussed in terms of their applicability to genetic end points and their ability to reflect the underlying basis of induced heritable translocations.