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Testing of sunset yellow and orange II for genotoxicity in different laboratory animal species
Author(s) -
Wever J.,
Münzner R.,
Renner H. W.
Publication year - 1989
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850130311
Subject(s) - genotoxicity , clastogen , orange (colour) , feces , biology , ames test , ingestion , bone marrow , salmonella , toxicology , chemistry , food science , toxicity , microbiology and biotechnology , biochemistry , genetics , immunology , organic chemistry , bacteria
The azo dyes Sunset Yellow and Orange II were gavaged to rodent species to check bile, urine, and fecal extracts for possible mutagenic activity in the Ames test or in bone marrow cells for clastogenicity using cytogenetic test systems. After oral application the dyes showed a negative response in bile, excrements, and bone marrow. When an exogenous metabolic activation was performed, increased revertant numbers using Salmonella strain TA100 were obtained only in fecal extracts of Sunset Yellow‐treated animals. It is concluded that no genotoxic harm is to be expected from the ingestion of Sunset Yellow or Orange II.