Premium
The effects of acrylamide on mouse germ‐line and somatic cell chromosomes
Author(s) -
Backer Lorraine C.,
Dearfield Kerry L.,
Erexson Gregory L.,
Campbell James A.,
WestbrookCollins Barbara,
Allen James W.
Publication year - 1989
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850130305
Subject(s) - somatic cell , micronucleus test , biology , meiosis , sister chromatids , germline , genetics , chromosome , synaptonemal complex , germ cell , chromosomal translocation , cytogenetics , chromatid , microbiology and biotechnology , chemistry , toxicity , gene , organic chemistry
The industrial chemical acrylamide is suspected to induce potentially heritable genetic damage. While several studies in rodents have indicated that this substance can damage spermiogenic cells, resulting in dominant lethals and heritable translocations, cytogenetic assessments of premeiotic and meiotic cells after exposure have produced equivocal results. In the present study, various cytogenetic endpoints in both somatic and germ‐line cells from acrylamide‐treated mice were evaluated. Sister chromatid exchanges and micronuclei, but not chromosome aberrations, were induced in spleen cells; synaptonemal complex irregularities (asynapsis), but not chromosome aberrations, were induced in germ cells.