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Absence of cinoxacin‐induced DNA fragmentation and mutations in the rat granuloma pouch
Author(s) -
Pino Albiana,
Maura Annalisa,
Grillo Patrizia
Publication year - 1989
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850130205
Subject(s) - granuloma , biology , dna fragmentation , dna damage , in vivo , dna , quinolone , microbiology and biotechnology , fragmentation (computing) , pouch , mutagen , genetics , immunology , antibiotics , anatomy , apoptosis , ecology , programmed cell death
The mutagenic and DNA‐damaging activities of cinoxacin were evaluated in the rat granuloma pouch assay (GPA) in order to assess its genotoxic potential in vivo. High doses of this antimicrobial quinolone, either directly injected into the pouch or administered by gavage, did not induce mutation at the hgprt locus or DNA fragmentation in granuloma cells. Moreover, DNA damage was absent in the liver and kidney of rats given cinoxacin by the oral route.