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Inhibition of aminoimidazoquinoxaline‐type and aminoimidazol‐4‐one type mutagen formation in liquid‐reflux models by the amino acids L‐proline and/or L‐tryptophan
Author(s) -
Jones R. Conrad,
Weisburger John H.
Publication year - 1988
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850110411
Subject(s) - mutagen , tryptophan , proline , chemistry , amino acid , reflux , biochemistry , biology , carcinogen , medicine , disease
Laboratory models were used to study the inhibition of mutagen formation by Maillard‐type reactions during cooking of meats or fish. The amino acid L‐proline (L‐pro) was an effective, dose‐dependent inhibitor of the development of mutagenicity (Ames test) in a liquid‐reflux model of glucose + glycine + creatinine known to produce IQ‐type mutagens (MeIQ x and 7,8‐DiMeIQ x ). L‐pro also inhibited formation of mutagens in a reflux model of threonine + creatinine, developed in our laboratory, which yields a novel class of IQ‐“like” aminoimidazol‐4‐one mutagens. A mixture of L‐pro and L‐tryptophan (L‐trp) at lower concentrations of each yielded increased inhibition, compared with the findings when each inhibitor was tested by itself.