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Clastogenicity of tritiated thymidine to the mouse bone marrow
Author(s) -
Ratpan Flora,
Ashby J.
Publication year - 1988
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850110209
Subject(s) - thymidine , clastogen , genotoxicity , bone marrow , in vivo , biology , micronucleus test , mutagen , in vitro , microbiology and biotechnology , toxicology , biochemistry , genetics , carcinogen , immunology , toxicity , medicine
Tritiated thymidine ( 3 HTdR; 120 μCi/mouse) increases the incidence of micronucleated polychromatic erythrocytes (MPE) in bone marrow PE of both B6CF1 and CBA male mice. This effect observed in vivo reflects the clastogenicity reported by other investigators for 3 HTdR in vitro. Thymidine itself was concluded to be inactive in the assay at a dose‐level 100 times greater than that required to show activity for 3 HTdR. These observations are of relevance to those employing 3 HTdR to monitor the mitogenic activity and the genotoxicity of chemicals.