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No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate
Author(s) -
Cain Katherine T.,
Cornett Carolyn V.,
Cacheiro Nestor L. A.,
Hughes Lori A.,
Owens James G.,
Generoso Walderico M.
Publication year - 1988
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850110206
Subject(s) - dominant lethal , genetics , biology , chromosomal translocation , mutation , mutagen , toxicology , gene , carcinogen
Abstract Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant‐lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubation with the maximum tolerated dose for 6 weeks. Calcium cyclamate is negative in both tests; therefore, there is no evidence of induced chromosome breakage and exchange.