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Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1‐methyl‐2‐pyrrolidinone and 2‐pyrrolidinone
Author(s) -
Mayer Ver W.,
Goin Carol J.,
TaylorMayer Rhoda E.
Publication year - 1988
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850110105
Subject(s) - aneuploidy , saccharomyces cerevisiae , succinimide , solvent , maleimide , yeast , chemistry , biochemistry , biology , genetics , stereochemistry , organic chemistry , chromosome , gene
A number of solvent compounds that were tested in Saccharomyces cerevisiae were potent inducers of aneuploidy, although they did not induce any other genetic effects. As an extention of these earlier findings, 1‐methyl‐2‐pyrrolidinone was tested and was found to induce aneuploidy. Several structurally related compounds were also tested; 2‐pyrrolidinone induced aneuploidy, but succinimide, pyrrolidine, 1‐methylpyrrolidine, 1‐methyl‐3‐pyrrolidinol, and 2‐pyrrolidineethanol did not. Maleimide and its N ‐hydroxy, N ‐methyl, and N ‐ethyl derivatives were also negative for aneuploidy induction.