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Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals
Author(s) -
Galloway S. M.,
Armstrong M. J.,
Reuben C.,
Colman S.,
Brown B.,
Can C.,
Bloom A. D.,
Nakamura F.,
Ahmed M.,
Duk S.,
Rimpo J.,
Margolin B. H.,
Resnick M. A.,
Anderson B.,
Zeiger E.
Publication year - 1987
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.2850100502
Subject(s) - chinese hamster ovary cell , sister chromatids , sister chromatid exchange , chromosome , genetics , biology , hamster , chromatid , chinese hamster , microbiology and biotechnology , dna , cell culture , gene
Abstract Results from the testing of 108 coded chemicals in Chinese hamster ovary (CHO) cells for the induction of chromosome aberrations and sister chromatid exchanges (SCEs) are presented. All chemicals were tested with and without exogenous metabolic activation, using protocols designed to allow testing up to toxic doses. Cell harvest times could also be extended if chemical‐induced cell cycle delay was seen. Chromosome aberrations were induced by 43 of the chemicals, and 66 induced SCEs; 37 of the chemicals were positive for both endpoints.